Related Research and Selected Relevant Literature

mRNA vaccines

Stuart, L M. 2021. In Gratitude for mRNA Vaccines. N Engl J Med. doi: 10.1056/NEJMcibr2111445

Dolgin. E. 2021. The tangled history of mRNA vaccines. Nature 597, 318-324. doi.org/10.1038/d41586-021-02483-w

Bozkurt B,Kamat I,Hotez P J. 2021. Myocarditis With COVID-19 mRNA Vaccines. Circulation 144(6):471–484. https://doi.org/10.1161/CIRCULATIONAHA.121.056135

Lazaros, G, Klein, A. et al. 2021. The Novel Platform of mRNA COVID-19 Vaccines and Myocarditis: Clues into the Potential Underlying Mechanism. Vaccine, 39(35), 4925–4927. https://doi.org/10.1016/j.vaccine.2021.07.016

STING and TBK1

Schmidt, A, Peters, S, Knaus, A et al. 2021. TBK1 and TNFRSF13B mutations and an autoinflammatory disease in a child with lethal COVID-19. Nature, npj Genom. Med. 6, 55. https://doi.org/10.1038/s41525-021-00220-w.

Decout, A., Katz, J.D., Venkatraman, S. et al. 2021. The cGAS–STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol 21, 548–569. https://doi.org/10.1038/s41577-021-00524-z.

Hertzog J, Rehwinkel J. 2020. Regulation and inhibition of the DNA sensor cGAS. EMBO Rep. 21(12):e51345. doi: 10.15252/embr.202051345.

Hasan M, Yan N. 2016. Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies. Pharmacol Res. 111:336-342. doi: 10.1016/j.phrs.2016.04.008.

Li, Y, Wilson, HL, Kiss-Toth, E. 2017. Regulating STING in health and disease. J Inflamm 14, 11. https://doi.org/10.1186/s12950-017-0159-2

Chin AC. 2019. Neuroinflammation and the cGAS-STING pathway. J Neurophysiol. 121(4):1087-1091. doi: 10.1152/jn.00848.2018.

Louis, C, Burns, C, & Wicks, I. 2018. TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity. Frontiers in Immunology, 9, 434. https://doi.org/10.3389/fimmu.2018.00434

Motwani, M, Pesiridis, S & Fitzgerald, KA. 2019. DNA sensing by the cGAS–STING pathway in health and disease Nat Rev Genet 20, 657–674. https://doi.org/10.1038/s41576-019-0151-1

Oligonucleotides (Synthetic RNAs)

Junt T, Barchet W. 2015. Translating nucleic acid-sensing pathways into therapies. Nat Rev Immunol. 15(9):529-44. doi: 10.1038/nri3875.

Roberts, T.C., Langer, R. & Wood, M.J.A. Advances in oligonucleotide drug delivery. Nat Rev Drug Discov 19, 673–694 (2020). https://doi.org/10.1038/s41573-020-0075-7

Li Q, Cao Y, Dang C, Han B, Han R, Ma H, Hao J, Wang L. 2020. Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke. EMBO Mol Med.;12(4):e11002. doi: 10.15252/emmm.201911002.

Wang F, Zuroske T, Watts JK. 2020. RNA therapeutics on the rise. Nature Reviews Drug Discovery 19, 441-442 (2020). doi: https://doi.org/10.1038/d41573-020-00078-0.

Feng, Y, & Chao, W. 2011. Toll-like receptors and myocardial inflammation. International journal of inflammation, 2011, 170352. https://doi.org/10.4061/2011/17035.